Publications of Natascia Ventura's group
2020
Schiavi A, Strappazzon F, Ventura N: Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies. Mech Ageing Dev 188: 111252, 2020. doi: 10.1016/j.mad.2020.111252
Merches K, Schiavi A, Weighardt H, Steinwachs S, Teichweyde N, Förster
I, Hochrath K, Schumak B, Ventura N, Petzsch P, Köhrer K, Esser C: AHR signaling dampens inflammatory signature in neonatal skin γδ T cells. Int J Mol Sci 21(6): 2249, 2020. doi: 10.3390/ijms21062249
Brinkmann V, Ale-Agha N, Haendeler J, Ventura N: The Aryl hydrocarbon Receptor (AhR) in the aging process: Another puzzling role for this highly conserved transcription factor. Front Physiol 10: 1561, 2020. doi: 10.3389/fphys.2019.01561
2019
Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N: Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging-US 11(16): 6535-6554, 2019. doi: 10.18632/aging.102208
Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G,
Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V,
Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl
T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S,
Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H,
Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura
N, Sigrist SJ, Kroemer G, Madeo F: The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun 10(1): 651, 2019. doi: 10.1038/s41467-019-08555-w
2018
Stork B, Ventura N: Targeting the BECN1-BCL2 autophagy regulatory complex to promote longevity. Biotarget 2: 16, 2018. doi: 10.21037/biotarget.2018.10.01
Torgovnick
A*, Schiavi A*, Shaik A#, Kassahun H#, Maglioni S, Rea SL, Johnson TE, Reinhardt
HC, Honnen S, Schumacher B, Nilsen H, Ventura N:
BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial
stress in Caenorhabditis elegans.
EMBO Rep 19(12): e45856, 2018. doi: 10.15252/embr.201845856 (*,# equal contribution)
Kassahun H, SenGupta T, Schiavi A, Maglioni S, Skjeldam HK, Arczewska K, Brockway NL, Estes S, Eide L, Ventura N, Nilsen H: Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans. DNA Repair (Amst) 61: 46-55, 2018. doi: 10.1016/j.dnarep.2017.11.009
2016
Kalfalah
F, Janke L, Schiavi A, Tigges J, Ix A, Ventura N, Boege F, Reinke H: Crosstalk of clock gene expression and
autophagy in aging. Aging (Albany NY)
8(9): 1876-1895, 2016. doi: 10.18632/aging.101018
Maglioni M, Arsalan N, Ventura N: C. elegans screening strategies to identify pro-longevity interventions. Mech Ageing Dev 157: 60-69, 2016. doi: 10.1016/j.mad.2016.07.010
Maglioni S, Ventura N: C. elegans as a model organism for human mitochondrial associated disorders. Mitochondrion 30: 117-125, 2016. doi: 10.1016/j.mito.2016.02.003
Klionski DJ et al.: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1): 1-222, 2016. doi: 10.1080/15548627.2015.1100356
Shaik A, Schiavi A, Ventura N: Mitochondrial autophagy promotes healthy aging (Editorial). Cell Cycle 15(4): 1805-1806, 2016. doi: 10.1080/15384101.2016.1181876
Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V,
Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura
N, Haendeler J: The aryl hydrocarbon receptor promotes aging phenotypes. Sci Rep 6: 19618, 2016. doi: 10.1038/srep19618
Schiavi A and Ventura N: Mitochondrial longevity pathways. In: Olsen A, Gill MS (Eds.): Ageing: Lessons from C. elegans. Springer International Publishing, Switzerland, 2016. ISBN print: 978-3-319-44701-8, pp 83-108.
2015
Van den Ecker D, Hoffmann M, Müting G, Maglioni S, Herebian D, Mayatepek E, Ventura N, Distelmaier F: C. elegans ATAD-3 modulates mitochondrial iron and heme homeostasis. Biochem Biophys Res Commun 467(2): 389-394, 2015. [pubmed]
Schiavi
A, Maglioni S, Palikaras K, Shaik A, Strapazzon F, Brinkmann V, Torgovnick A,
Castelein N, De Henau S, Braeckman BP, Cecconi F, Tavernarakis N, Ventura N: Iron
starvation-induced mitophagy mediates lifespan extension upon mitochondrial
stress in C. elegans. Curr Biol 25(14): 1810-1822, 2015. [pubmed]
Maglioni S, Arsalan N, Franchi L, Hurd A, Opipari AW, Glick GD, Ventura N:
An automated phenotype-based microscopy screen to identify pro-longevity
interventions acting through mitochondria in C. elegans. Biochim Biophys
Acta-Bioenerg 1847(11): 1469-1478, 2015. [pubmed]
2014
Maglioni S, Schiavi A, Runci A, Shaik A, Ventura N: Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis. Exp Gerontol 56: 89-98, 2014. [pubmed]
Schiavi A, Ventura N: The interplay between mitochondria and autophagy and its role in the aging process. Exp Gerontol 56: 147-153, 2014. [pubmed]
Trifunovic A, Ventura N: Mitochondria and metabolic control of the aging process (editorial). Exp Gerontol 56: 1-2, 2014. [pubmed]
Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F: The Hallmarks of Fibroblast Ageing. Mech Ageing Dev 138: 26-44, 2014. [pubmed]
2013
Arczewska KD, Tomazella GG, Lindvall JM, Kassahun H, Maglioni S, Torgovnick A, Henriksson J, Matilainen O, Marquis BJ, Nelson BC, Jaruga P, Babaie E, Holmberg CI, Bürglin TR, Ventura N, Thiede B, Nilsen H: Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1. Nucleic Acids Res 41(10): 5368-5381, 2013. [pubmed]
Di Gregorio E, Bianchi FT, Schiavi A, Chiotto AM, Rolando M, Verdun di Cantogno L, Grosso E, Cavalieri S, Calcia A, Lacerenza D, Zuffardi O, Retta SF, Stevanin G, Marelli C, Durr A, Forlani S, Chelly J, Montarolo F, Tempia F, Beggs HE, Reed R, Squadrone S, Abete MC, Brussino A, Ventura N, Di Cunto F, Brusco A: A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia. J Med Genet 50(8): 543-551, 2013. [pubmed]
Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condo I, Bei R, Rea S, Braeckman BP, Tavernarakis N, Testi R, Ventura N: Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans. Exp Gerontol 48(2): 191-201, 2013. [pubmed]
Torgovnick A, Schiavi A, Maglioni S, Ventura N: Healthy aging: what can we learn from C. elegans? Z Gerontol Geriat 46(7): 623-628, 2013. [pubmed]
Publications before 2012
Ottaviani E, Ventura N,
Mandrioli M, Candela M, Franchini A, and Franceschi C. Gut microbiota as a
candidate for lifespan extension: an ecological/evolutionary perspective
targeted on living organisms as metaorganisms. Biogerontology. 2011 Dec;12(6): 599-609.
Guccini I, Serio D, Condò I, Rufini A, Tomassini B, Mangiola A, Maira G,
Anile C, Fina D, Pallone F, Mongiardi MP, Levi A, Ventura N@, Testi R@, Malisan F@. Frataxin
participates to the hypoxia-induced response in tumors. Cell Death Dis. 2011 Feb 24;2:e123.
Rufini A*, Fortuni S*, Arcuri G, Condo’ I, Serio D, Incani O, Malisan M,
Ventura N, Testi R. Preventing the
ubiquitin/proteasome-dependent degradation of frataxin, the protein defective
in Friedreich’s Ataxia. Hum Mol Genet.
2011 Apr 1;20(7):1253-61
Butler JA, Ventura
N, Johnson TE, Rea SL. The Long-lived mitochondrial (MIT)
mutants of C. elegans utilize a novel
metabolism. FASEB J. 2010
Dec;24(12):4977-88
Torgovnick A, Schiavi A, Testi R, Ventura N. A role for p53 in mitochondrial
stress response control of longevity in C.
elegans. Exp Gerontol. 2010
Aug;45(7-8):550-7
Ventura N@, Rea SL, Schiavi A, Torgovnick A, Testi R, Johnson
TE. p53/cep-1 increases or decreases C. elegans lifespan depending on level of mitochondrial bioenergetic stress. Aging Cell. 2009 Aug;8(4):380-93
Rea SL*, Ventura N*, Johnson TE. Relationship Between Mitochondrial Inhibition,
Development and Life Extension in C.
elegans. PloS Biology. 2007 Oct
2;5(10):e259
Kell A, Ventura N, Johnson TE. Activation of Skn-1 by novel kinases in Caenorhabditis elegans. Free Radic Biol Med. 2007 Dec
1;43(11):1560-6.
Ventura N*@, Rea SL*. C. elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Biotechnol J. 2007 May;2(5):584-95
Condò I, Ventura N, Malisan F, Rufini A, Tomassini B, Testi R. In vivo
maturation of human frataxin. Hum Mol
Genet 2007 Jul 1;16(13):1534-40
Condò I*, Ventura N*, Malisan F, Tomassini B, Testi
R. A pool of extramitochondrial frataxin that protect from apopotsis. J Biol Chem. 2006 Jun16;281(24):16750-6
Ventura N, Rea SL, Henderson ST, Condo I, Testi R, Johnson
TE. C. elegans as a model for
Friedreich Ataxia. FASEB J 2006
May; 20(7):1029-30.
Ventura N@, Rea SL, Testi R. Long-lived C. elegans mitochondrial
mutants as a model for human mitochondrial-associated diseases. Exp Gerontol 2006 Oct;41(10):974-91
Ventura
N, Rea
S, Henderson ST, Condo I, Johnson TE, Testi R. Reduced Expression of
Frataxin Extends the Life Span of Caenorhabditis
elegans. Aging Cell 2005 Apr;4(2):109-12.
Barilà D, Rufini A, Condò I, Ventura N, Dorey K, Superti-Furga G and Testi R. Caspase-dependent cleavage of c-Abl
contributes to apoptosis. Mol Cell Biol
2003 Apr;23(8):2790-9.
Cicconi S, Ventura
N, Pastore D, Bonini P, Pierucci D, Merlo D, Di Nardo P, Lauro R, Borboni
P. Marlier NJL. Characterization of
apoptosis signal transduction pathways in HL-5 cardiomyocytes exposed to
ischemia/reperfusion oxidative stress model. J Cell Physiol 2003 Apr;195(1):27-37
Malisan F, Franchi L, Tomassini B, Ventura
N, Condo' I, Rippo MR, Rufini A, Liberati L, Nachtigall C, Kniep B, Testi R. Acetylation suppresses the pro-apoptotic activity of GD3 ganglioside. J Exp Med 2002 196(12):1535-41
*equal contribution; @corresponding author
