Publications of Heike Weighardt's group

2018

Fülle L, Steiner N, Funke M, Gondorf F, Pfeiffer F, Siegl J, Opitz FV, Haßel SK, Erazo AB, Schanz O, Stunden HJ, Blank M, Gröber C, Händler K, Beyer M, Weighardt H, Latz E, Schultze JL, Mayer G, Förster I: RNA aptamers recognizing murine CCL17 inhibit T cell chemotaxis and reduce contact hypersensitivity in vivo. Mol Ther 26(1): 95-104, 2018. doi: 10.1016/j.ymthe.2017.10.005

2017

Faßbender S, Opitz FV, Johnen S, Förster I, Weighardt H: MyD88 contributes to staphylococcal enterotoxin B-triggered atopic dermatitis-like skin inflammation in mice. J Invest Dermatol 137(8): 1802-1804, 2017. doi: 10.1016/j.jid.2017.04.015

Koch S, Stroisch TJ, Vorac J, Herrmann N, Leib N, Schnautz S, Kirins H, Förster I, Weighardt H, Bieber T: AhR mediates an anti-inflammatory feedback mechanism in human Langerhans cells involving FcεRI and IDO. Allergy 72(11): 1686-1693, 2017. doi: 10.1111/all.13170

Merches K, Haarmann-Stemmann T, Weighardt H, Krutmann J, Esser C: AHR in the skin: From the mediator of chloracne to a therapeutic panacea? Current Opinion Toxicol 2: 79-86, 2017. doi: 10.1016/j.cotox.2017.02.002

2016

Haas K, Weighardt H, Deenen R, Köhrer K, Clausen B, Zahner S, Boukamp P, Bloch W, Krutmann J, Esser C: Aryl hydrocarbon receptor in keratinocytes is essential for murine skin barrier integrity. J Invest Dermatol 136(11): 2260-2269, 2016. doi: 10.1016/j.jid.2016.06.627

Brandstätter O*, Schanz O*, Vorac J*, König J, Mori T, Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H, Weighardt H*, Förster I*: Balancing intestinal and systemic inflammation through cell typespecific expression of the aryl hydrocarbon receptor repressor. Sci Rep 6: 26091, 2016. doi: 10.1038/srep26091 (* equal contribution)

Didovic S*, Opitz FV*, Holzmann B, Förster I, Weighardt H: Requirement of MyD88 signaling in keratinocytes for Langerhans cell migration and initiation of atopic dermatitis-like symptoms in mice. Eur J Immunol 46(4): 981-992, 2016. doi: 10.1002/eji.201545710 (* equal contribution)

2015

Weighardt H, Förster I: Bcl-3 puts the brakes on contact hypersensitivity. Eur J Immunol 45(4): 971-974, 2015. [pubmed]

Kroker M, Sydlik U, Autengruber A, Cavelius C, Weighardt H, Kraegeloh A, Unfried K: Preventing carbon nanoparticle-induced lung inflammation reduces antigen-specific sensitization and subsequent allergic reactions in a mouse model. Part Fibre Toxicol 12(1): 20, 2015. [pubmed] (open access)

2014

Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T: Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 507(7490): 109-113, 2014. [pubmed]
 

Sommer D, Peters A, Wirtz T, Mai M, Ackermann J, Thabet Y, Schmidt J, Weighardt H, Wunderlich FT, Degen J, Schultze JL, Beyer M: Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nat Commun 66C: 97-106, 2014. [pubmed]
 

Globisch T, Steiner N, Fülle L, Lukacs-Kornek V, Degrandi D, Dresing P, Alferink J, Lang R, Pfeffer K, Beyer M, Weighardt H, Kurts C, Ulas T, Schultze JL, Förster I: Cytokine-dependent regulation of denditic cell differentiation in the splenic microenvironment. Eur J Immunol 44(2): 500-510, 2014. [pubmed]
 

Macpherson L, Ahmed S, Tamblyn L, Krutmann J, Förster I, Weighardt H, Matthews J: Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling. Int J Mol Sci 15(5): 7939-7957, 2014. [pubmed]

2013

Wohn C, Ober-Blöbaum JL, Haak S, Pantelyushin S, Cheong C, Zahner SP, Onderwater S, Kant M, Weighardt H, Holzmann B, Reizis B, Becher B, Prens EP, Clausen BE: Langerinneg conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice. Proc Natl Acad Sci USA 110(26): 10723-10728, 2013. [pubmed]
 

Tigges J, Weighardt H, Wolff S, Goetz C, Foerster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, Fritsche E: Arylhydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. J Invest Dermatol 133(1):87-96, 2013. [pubmed]
 

Esser C, Bargen I, Weighardt H, Haarmann-Stemmann T, Krutmann J: Functions of the Aryl Hydrocarbon Receptor in the skin. Seminars in Immunopathology 35(6): 677-691, 2013. [pubmed]
 

Wilhelmi V, Fischer U, Weighardt H, Schulze-Osthoff K, Nickel C, Stahlmecke B, Kuhlbusch TA, Scherbart AM, Esser C, Schins RPF, Albrecht C. Zinc Oxide Nanoparticles Induce Necrosis and Apoptosis in Macrophages in a p47phox- and Nrf2-Independent Manner. PLoS One 8(6): e65704, 2013. [pubmed]

2012

Tigges J*, Weighardt H*, Wolff S, Gotz C, Forster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, and Fritsche E: Aryl Hydrocarbon Receptor Repressor (AhRR) Function Revisited: Repression of CYP1 Activity in Human Skin Fibroblasts Is Not Related to AhRR Expression. J Invest Dermatol 133(1): 87-96, 2012. (*equal contribution) [pubmed] (open access)

Gais P, Reim D, Jusek G, Rossmann-Bloeck T, Weighardt H, Pfeffer K, Altmayr F, Janssen KP, Holzmann B: Cutting edge: divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis. J Immunol 188(12): 5833-5837, 2012. [pubmed]
 

Köhler T, Reizis B, Johnson RS, Weighardt H, Förster I: Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration. Eur J Immunol 42(5): 1226-1236, 2012. [pubmed]


2010

Gais P, Tiedje C, Altmayr F, Gaestel M, Weighardt H, Holzmann B: TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. J Immunol 184 (10): 5842-5848, 2010.
 

Chmill S, Kadow S, Winter M, Weighardt H, Esser C: 2,3,7,8-Tetrachlorodibenzo-P-dioxin impairs stable establishment of oral tolerance in mice. Toxicol Sci 118(1):98-107, 2010.
 

Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R: Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology 131(3):395-404, 2010.

2009

Reim D, Westenfelder K, Kaiser-Moore S, Schlautkötter S, Holzmann B, Weighardt H: Role of T cells for cytokine production and outcome in a model of acute septic peritonitis. Shock 31 (3): 245-250, 2009.

2008

Lochner M, Kastenmüller K, Neuenhahn M, Weighardt H, Busch DH, Reindl W, Förster I: Decreased susceptibility of mice towards infection with Listeria monocytogenes in the absence of Interleukin-18. Infect Immun 76(9): 3881-3890, 2008.
 

Weighardt H, Holzmann B: Role of Toll-like Receptor Responses for Sepsis Pathogenesis. Immunobiology 212 (9-10): 715-722, 2008.

2007

Schröder K, Spille M, Pilz A, Lattin J, Bode KA, Irvine KM, Burrows AD, Ravasi T, Weighardt H, Stacey KJ, Decker T, Hume DA, Dalpke AH, Sweet MJ: Differential Effects of CpG DNA on IFN-beta Induction and STAT1 Activation in Murine Macrophages versus Dendritic Cells: Alternatively Activated STAT1 Negatively Regulates TLR Signaling in Macrophages. Journal of Immunology 179 (6): 3495-34503, 2007.
 

Weber GF, Schlautkotter S, Kaiser-Moore S, Altmayr F, Holzmann B, Weighardt H: Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis. Infect Immun 75 (4): 1690-1697, 2007.
 

Novotny AR, Emmanuel K, Maier S, Westerholt A, Weighardt H, Stadler J, Bartels H, Schwaiger M, Siewert JR, Holzmann B, Heidecke CD: Cytochrome P450 activity mirrors nitric oxide levels in postoperative sepsis: predictive indicators of lethal outcome. Surgery 141 (3): 376-843, 2007.
 

Novotny A, Emmanuel K, Matevossian E, Kriner M, Ulm K, Bartels H, Holzmann B, Weighardt H, Siewert JR: Use of procalcitonin for early prediction of lethal outcome of postoperative sepsis.  Am J Surg 194 (1): 35-39, 2007.