Team Unfried - publications

2018

Spannbrucker T*, Ale-Agha N*, Goy C, Dyballa-Rukes N, Jakobs P, Jander K, Altschmied J, Unfried K, Haendeler J: Induction of a senescent like phenotype and loss of gap junctional intercellular communication by carbon nanoparticle exposure of lung epithelial cells. Exp Gerontol 2018. doi: 10.1016/j.exger.2018.11.017 (*equal contribution)

Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, Aufenvenne K, von Ameln F, Zurek M, Spannbrucker T, Eckermann O, Jakob S, Gorressen S, Abrams M, Grandoch M, Fischer JW, Köhrer K, Deenen R, Unfried K, Altschmied J, Haendeler J: CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system - New mode of action for caffeine. Plos Biol 16(6): e2004408. doi: 10.1371/journal.pbio.2004408

Hanžić N, Horvat A, Bibić J, Unfried K, Jurkin T, Dražić G, Marijanović I, Slade N, Gotić M: Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation. Mater Sci Eng C 91: 486-495, 2018. doi: 10.1016/j.msec.2018.05.066

Stöckmann D, Spannbrucker T, Ale-Agha N, Jakobs P, Goy C, Dyballa-Rukes N, Hornstein T, Kümper A, Kraegeloh A, Haendeler J, Unfried K: Non-canonical activation of the epidermal growth factor receptor by carbon nanoparticles. Nanomaterials 8(4): 267, 2018. doi: 10.3390/nano8040267

2017

Kraegeloh A, Unfried K: The safety of nanomaterials on molecular and cellular scale. In: Gogotsi Y (Editor) Nanomaterials handbook 2nd edition, CRC Press, USA, 2017. ISBN 9781498703062, pp 629-652.

2016

Kraegeloh A, Unfried K: The Safety of Nanomaterials on Molecular and Cellular Scale. In: Gogotsi Y (Editor) Nanomaterials Handbook 2nd Edition, CRC Press, USA, 2017. ISBN 9781498703062

Unfried K, Krämer U, Sydlik U, Autengruber A, Bilstein A, Stolz S, Marini A, Schikowski T, Keymel S, Krutmann J: Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individuals. Int J Chronic Obstr Pulm Dis 11(1): 2573-2583, 2016. doi: 10.2147/COPD.S115061

Barenys M, Gassmann K, Baksmeier C, Heinz S, Reverte I, Schmuck M, Temme T, Bendt F, Zschauer TC, Rockel TD, Unfried K, Wätjen W, Sundaram SM, Heuer H, Colomina MT, Fritsche E: Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro. Arch Toxicol 2016. doi: 10.​1007/​s00204-016-1709-8

Hornstein T, Lehmann S, Philipp D, Detmer S, Hoffmann M, Peter C, Wesselborg S, Unfried K, Windolf J, Flohé S, Paunel-Görgülü A: Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation. J Leukoc Biol 99(1): 163-174, 2016. doi: 10.1189/jlb.3A1114-537RR

2015

Kroker M, Sydlik U, Autengruber A, Cavelius C, Weighardt H, Kraegeloh A, Unfried K: Preventing carbon nanoparticle-induced lung inflammation reduces antigen-specific sensitization and subsequent allergic reactions in a mouse model. Part Fibre Toxicol 12(1): 20, 2015. [pubmed] (open access)

2014

Gassmann K, Schreiber T, Dingemans MML, Krause G, Roderigo C, Giersiefer S, Schuwald J, Moors M, Unfried K, Bergman A, Westerink RHS, Rose CR, Fritsche E: BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms. Arch Toxicol 88: 1537-1548, 2014. [pubmed]
 

Autengruber A, Sydlik U, Kroker M, Hornstein T, Ale-Agha N, Stöckmann D, Bilstein A, Albrecht C, Paunel-Görgülü A, Suschek CV, Krutmann J, Unfried K: Signalling-dependent adverse health effects of carbon nanoparticles are prevented by the compatible solute beta mannosylglycerate (firoin) in vitro and in vivo. Plos one 9(11): e111485, 2014. [pubmed]
 

Unfried K, Kroker M, Autengruber A, Gotic M, Sydlik U: The compatible solute ectoine reduces the exacerbating effects of environmental model particles on the immune response of the airways. J Allergy 2014: 708458. [pubmed] (open access)

2013

Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J, Haarmann-Stemmann T: Evidence for a novel anti-apoptotic pathway in keratinocytes involving the aryl hydrocarbon receptor, E2F1 and checkpoint kinase 1. Cell Death & Differentiation 20(10): 1425-1434, 2013. [pubmed]
 

Sydlik U, Peuschel H, Paunel-Görgülü A, Keymel S, Krämer U, Weissenberg A, Kroker M, Seghrouchni S, Heiss C, Windolf J, Bilstein A, Kelm M, Krutmann J, Unfried K: Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation. Eur Respir J 41(2): 433-442, 2013. [pubmed]
 

Stobbe-Maicherski N, Wolff S, Wolff C, Abel J, Sydlik U, Frauenstein K, Haarmann-Stemmann T: The IL-6-type cytokine oncostatin M induces aryl hydrocarbon receptor expression in a STAT3-dependent manner in human HepG2 hepatoma cells. FEBS Journal 280(24): 6681-6690, 2013. [pubmed]
 

Büchner N, Ale-Agha N, Jakob S, Sydlik U, Kunze K, Unfried K, Altschmied J, Haendeler J: Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes.Exp Gerontol 48(1): 8-16, 2013. [pubmed]
 

Gotic M, Jurkin T, Music S, Unfried K, Sydlik U, Bauer-Segvic A: Microstructural characterizations of different Mn-oxide nanoparticles used as models in toxicity studies. J Molecular Structure 1044: 248-254, 2013.

2012

Peuschel H, Sydlik U, Grether-Beck S, Felsner I, Stöckmann D, Jakob S, Kroker M, Haendeler J, Gotic M, Bieschke C, Krutmann J, Unfried K: Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation. Part Fibre Toxicol 9(1): 48, 2012. [pubmed]
 

Haendeler J, Eckers A, Lukosz M, Unfried K, Altschmied J: Endothelial NADPH oxidase 2 – when does it matter in atherosclerosis? Cardiovasc Res 94(1):1-2, 2012.
 

2010

Weissenberg A, Sydlik U, Peuschel H, Schroeder P, Schneider M, Schins RP, Abel J, Unfried K: Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles. Free Radic Biol Med 49: 597–605, 2010.
 

Peuschel H, Sydlik U, Haendeler J, Büchner N, Stökmann D, Kroker M, Wirth R, Brock W, Unfried K: c-Src-mediated activation of Erk1/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategy. Biol Chem 391 (11): 1327-1332, 2010.

2009

Sydlik U, Gallitz I, Albrecht C, Abel J, Krutmann J, Unfried K: The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation. Am J Respir Crit Care Med 180 (1): 29-35, 2009.

2008

Unfried K, Sydlik U, Bierhals K, Weissenberg A, Abel J: Carbon nanoparticle-induced lung epithelial cell proliferation is mediated by receptor-dependent AKT activation. Am J Physiol – Lung Cell Mol Biol 294: L358-367, 2008.
 

Rabstein S, Unfried K, Ranft U, Illig T, Kolz M, MambetovaC, Vlad M, Roman C, Weiss T, Becker D, Brüning T, Pesch B:  Lack of association of delta-aminolevulinate dehydratase polymorphisms with blood lead levels and hemoglobin in romanian women from a lead-contaminated region. J Toxicol Environ Health A 71(11): 716 - 724, 2008.

2007

Unfried K, Albrecht C, Klotz LO, von Mikecz A, Grether-Beck S, Schins RPF: Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 1: 52-71, 2007.

2006

Rabstein S, Unfried K, Ranft U, Illig T, Kolz M, Rihs H-P, Mambetova C, Vlad M, Brüning T, Pesch B: Variation of the N-acetyltransferase 2 (NAT2) Gene in unrelated Kyrgyz and Romanian individuals: from single nucleotide polymorphisms to predicted phenotype. Cancer Epidemiology Biomarkers Prevention 15 (1): 138-141, 2006.
 

Sydlik U, Bierhals K, Soufi M, Abel J, Schins R, Unfried K: Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R. Am J Physiol Lung Cell Mol Physiol 291(4): L725-L733, 2006.