Publications of Thomas Haarmann-Stemmann's group

2018

Pollet M*, Shaik S*, Mescher M*, Frauenstein K, Tigges J, Braun S, Sondenheimer K, Kaveh M, Bruhs A, Meller S, Homey B, Schwarz A, Esser C, Douki T, Vogel CF, Krutmann J, Haarmann-Stemmann T: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ 25: 1823-1836, 2018. doi: 10.1038/s41418-018-0160-1 (* equal contribution)

Pollet M, Krutmann J, Haarmann-Stemmann T: Commentary: Usage of mitogen-activated protein kinase small inhibitors: More than just inhibition!” Front Pharmacol 9: 935, 2018. doi: 10.3389/fphar.2018.00935

Mescher M, Haarmann-Stemmann T: Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options. Pharmacol Ther 187: 71-87, 2018. doi: 10.1016/j.pharmthera.2018.02.012

Esser C, Haarmann-Stemmann T, Hochrath K, Schikowski T, Krutmann J: AHR and the issue of immunotoxicity. Curr Opinion Toxicol 10: 91-97, 2018. doi: 10.1016/j.cotox.2018.03.001

Nakamura M*, Haarmann-Stemmann T*, Krutmann J, Morita A: Alternative test models for skin aging research. Exp Dermatol 27: 495-500, 2018. doi: 10.1111/exd.13519 (* equal contribution)

2017

Vogel CFA, Haarmann-Stemmann T: The aryl hydrocarbon receptor repressor - More than a simple feedback inhibitor of AHR signaling: Clues for its role in inflammation and cancer. Current Opinion Toxicol 2: 109-119, 2017. doi: 10.1016/j.cotox.2017.02.004

Merches K, Haarmann-Stemmann T, Weighardt H, Krutmann J, Esser C: AHR in the skin: From the mediator of chloracne to a therapeutic panacea? Current Opinion Toxicol 2: 79-86, 2017. doi: 10.1016/j.cotox.2017.02.002

2016

Brandstätter O*, Schanz O*, Vorac J*, König J, Mori T, Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H, Weighardt H*, Förster I*: Balancing intestinal and systemic inflammation through cell typespecific expression of the aryl hydrocarbon receptor repressor. Sci Rep 6: 26091, 2016. doi: 10.1038/srep26091 (* equal contribution)

Vogel CFA, Chang WLW, Kado S, McKulloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang GX, Leung PSC, Matsumura F, Gershwin ME: Transgenic overexpression of aryl hydrocarbon receptor repressor (AhRR) and AhR-mediated induction of CYP1A1, cytokines and acute toxicity. Environ Health Perspect 124(7): 1071-1083, 2016. doi: 10.1289/ehp.1510194

Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V, Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura N, Haendeler J: The aryl hydrocarbon receptor promotes aging phenotypes. Sci Rep 6: 19618, 2016. doi: 10.1038/srep19618

Dittmann KH, Rothmund MC, Paasch A, Mayer C, Fehrenbacher B, Schaller M, Frauenstein K, Fritsche E, Haarmann-Stemmann T, Braeuning A, Rodemann HP: The nuclear aryl hydrocarbon receptor is involved in regulation of DNA-repair and cell survival following treatment with ionizing radiation. Toxicol Lett 240(1): 122-129, 2016. doi: 10.1016/j.toxlet.2015.10.017

2015

Haarmann-Stemmann T, Esser C, Krutmann J: The Janus-faced role of Aryl Hydrocarbon Receptor (AHR) signaling in the skin: Consequences for prevention and treatment of skin disorders. J Invest Dermatol 135(11): 2572-2576, 2015. [pubmed]

Nakamura M, Haarmann-Stemmann T, Krutmann J: COX inhibition enhances inflammatory immune cell infiltration in UV-irradiated human skin: implications for the treatment of sunburn. Exp Dermatol 24(10): 734-735, 2015. [pubmed] (open access)

Bekki K, Vogel H, Li W, Ito T, Sweeney C, Haarmann-Stemmann T, Matsumura F, Vogel CF: The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells. Pestic Biochem Physiol 120: 5-13, 2015. [pubmed]

Frauenstein K*, Tigges J*, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison MS, Vogel CFA, Haarmann-Stemmann T: Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2). Arch Toxicol 89(8): 1329-1336, 2015 (* equal contribution) [pubmed]

Nakamura M, Morita A, Seité S, Haarmann-Stemmann T, Grether-Beck S, Krutmann J: Environment-Induced Lentigines (EILs): Formation of solar lentigines beyond ultraviolet radiation. Exp Dermatol 24(6): 407-411, 2015. [pubmed]

Bruhs A, Haarmann-Stemmann T, Frauenstein K, Krutmann J, Schwarz T, Schwarz A: Activation of the arylhydrocarbon receptor causes immunosuppression primarily by modulating dendritic cells. J Invest Dermatol 135(2): 435-444, 2015. [pubmed]

2014

Tigges J*, Haarmann-Stemmann T*, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J*, Fritsche E*: The new arylhydrocarbon receptor (AhR) antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one (BDDI) protects against UVB-induced signal transduction. J Invest Dermatol 134(2): 556-559, 2014. (* equal contribution) [pubmed] (open access)
 

Vogel CFA, Kahn EM, Leung P, Gershwin ME, Chang WLW, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS: Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for NF-κB. Journal of Biological Chemistry 289(3): 1866-1875, 2014. [pubmed] (open access)

2013

Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J, Haarmann-Stemmann T: Evidence for a novel anti-apoptotic pathway in keratinocytes involving the aryl hydrocarbon receptor, E2F1 and checkpoint kinase 1. Cell Death & Differentiation 20(10): 1425-1434, 2013. [pubmed] (open access)
 

Haarmann-Stemmann T, Boege F, Krutmann J: Adaptive and maladaptive responses in sSkin: Mild heat exposure protects against UVB-induced photoaging in mice. J Invest Dermatol 133(4): 868-871, 2013. [pubmed]
 

Tigges J*, Weighardt H*, Wolff S, Goetz C, Foerster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, Fritsche E: Arylhydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. J Invest Dermatol 133(1): 87-96, 2013. (*equal contribution) [pubmed] (open access)
 

Esser C, Bargen I, Weighardt H, Haarmann-Stemmann T, Krutmann J: Functions of the Aryl Hydrocarbon Receptor in the skin. Seminars in Immunopathology 35(6): 677-691, 2013. [pubmed]
 

Stobbe-Maicherski N, Wolff S, Wolff C, Abel J, Sydlik U, Frauenstein K, Haarmann-Stemmann T: The IL-6-type cytokine oncostatin M induces AHR expression in a STAT3-dependent manner in human HepG2 hepatoma cells. FEBS Journal 280(24): 6681-6690, 2013. [pubmed]
 

Vrzal R*, Frauenstein K*, Proksch P, Abel J, Dvorak Z, Haarmann-Stemmann T: Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One 8(9): e74917, 2013. (*authors contributed equally) [pubmed]
 

Ono Y, Torii K, Fritsche E, Shintani Y, Nishida E, Nakamura M, Shirakata Y, Haarmann-Stemmann T, Abel J, Krutmann J, Morita A: Role of the aryl hydrocarbon receptor in tobacco smoke extract-induced matrix metalloproteinase-1 expression.Exp Dermatol 22(5): 349-353, 2013. [pubmed]
 

2012

Haarmann-Stemmann T, Abel J, Fritsche E, Krutmann J: The AhR-Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention? J Invest Dermatol 132 (1): 7-9, 2012. [pubmed]
 

2011

Bothe H*, Gassmann K*, Götz C, Fritsche E, Abel J, Haarmann-Stemmann T: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. Toxicology Letters 203(3): 258-264, 2011. (*equal contribution) [pubmed]
 

Haarmann-Stemmann T, Abel J: Influence of HIF-1a and Nrf2 on AHR mediated gene expression, toxicity and biological functions. In: The AH Receptor in Biology and Toxicology. Raimo Pohjanvirta (ed). Wiley-VCH, Weinheim 2011, ISBN 978-0-470-60182-2  

2010

Gassmann K, Abel J, Bothe H, Haarmann-Stemmann T, Merk HF, Quasthoff KN, Rockel TD, Schreiber T, Fritsche E: Species-specific differential AhR-expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. Environ Health Perspect 118(11): 1571-1577, 2010.
 

Haarmann-Stemmann T, Sendker J, Götz C, Krug N, Bothe H, Fritsche E, Proksch P, Abel J: Regulation of human dioxin receptor function by different beta-carboline alkaloids. Archives of Toxicology 84 (8): 619-629, 2010.
 

Bothe H, Götz C, Stobbe-Maicherski N, Fritsche E, Abel J, Haarmann-Stemmann T: Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. Archives of Biochemistry and Biophysics 498 (2): 111-118, 2010.
 

Abel J, Haarmann-Stemmann T: An introduction to the molecular basics of Arylhydrocarbon Receptor biology. Biological Chemistry 391(11):1235-48, 2010.

2009

Haarmann-Stemmann T, Bothe H, Abel J: Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochemical Pharmacology 77 (4): 508-520, 2009.

2007

Haarmann-Stemmann T, Bothe H, Kohli A, Sydlik U, Abel J, Fritsche E: Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines. Drug Metabolism and Disposition 35: 2262-2269, 2007.

2006

Haarmann-Stemmann T, Abel J: The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function. Biological Chemistry 387: 1195-1199, 2011.