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PhD student (Master's in Biology/Biochemistry/Biotechnology or similar) (f/m/d)

In the context of a collaboration with the Institute of Stem Cell Research and Regenerative Medicine and Prof. James Adjaye, Chair of Stem Cell Research and Regenerative Medicine, at Heinrich Heine University Düsseldorf, the IUF is offering a position for a PhD student (Master's in Biology/Biochemistry/Biotechnology or similar) (f/m/d). The contract will be given by the IUF but the daily work will be carried out at ISRM, the applicant will have access to facilities at both IUF and ISRM.

The project:

Cockayne Syndrome B (CSB) belongs to the nucleotide excision repair syndromes and skin cells of CSB patients are not capable of properly repairing UV-induced DNA damage. Clinically, CSB patients are characterized by progeria, reduced life expectancy and severe neurological symptoms. The neurological symptoms significantly determine the quality of life of patients. However, the loss of DNA repair capacity alone does not suffice to explain the neurological symptoms of CSB patients. This project therefore aims to elucidate the molecular and cellular mechanisms underlying the neurological symptoms of CSB patients.

Candidate Profile:

Our research group is looking for a motivated candidate who is highly committed and motivated, enjoys their work and has great communication skills and team spirit. The applicant should hold a degree in biology/biochemistry/biotechnology or similar. Very good English language skills and experience with cell culture, especially human-induced pluripotent stem cell culture, 3D cell culture, microscopy and common molecular biological methods are desirable.

What we offer:

We are an interdisciplinary team with a positive work environment. We offer the candidate thorough training introducing them to a highly topical and challenging field of work. Our cutting-edge cell culture models will be used to work on the research question. The project will be carried out in a team comprising other scientists, with intensive exchange of information about project-relevant results across different models and species.

The position is limited to 3 years. The weekly working time totals 25 hours and 54 minutes. Remuneration is given in accordance with the provisions of the collective agreement for the employees of the states (TV-L). Salary will be according to TV-L (E13).

Please address your application (incl. letter of motivation, CV, references, qualification certificates), preferably via email to

Kerstin Röder-Rutha
Head of Human Resources
IUF – Leibniz-Institut für umweltmedizinische Forschung
c/o Personalstelle
Auf’m Hennekamp 50
40225 Düsseldorf

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.

Student (f/m/d) for Master Thesis

The working group “Modern risk assessment and sphere biology” at the IUF - Leibniz Research Institute for Environmental Medicine in Düsseldorf is looking for a student (f/m/d) for a Master Thesis in the field of embryotoxic hazard assessment.

Thesis topic:

The human induced pluripotent stem cell (hiPS) test for embryotoxic hazard assessment.

Background to the topic:

Due to chemical regulations from international agencies the amount of animal testing for developmental toxicity is intense, using a high number of animals, time and money. To provide an alternative, e.g. for screening and prioritization, we are establishing the human induced pluripotent stem cell (hiPS) test as a human orthogonal assay for the mouse embryonic stem cell test (mEST), which is based on mouse embryonic stem cells differentiating into cardiomyocytes. This test was previously validated by ECVAM as an alternative method for embryotoxicity testing. However, due to the issue of species differences, alternative methods based on human cells are preferred. Human iPSC bear no ethical concerns and deliver unrestricted amounts of cell material. Therefore, they are currently the preferred source of human cell material.

The project:

In this master thesis you will learn how to handle hiPSC. You will differentiate hiPSC into beating cardiomyocytes in culture. Using this protocol for screening, you will test substances for their hazard on human cardiomyocyte differentiation. Endpoint determinations on day 10 of the protocol include measures of cell viability and cytotoxicity, FACS analyses, PCR and video analyses using ImageJ. You will learn about hazard identification and basic risk assessment processes.

You will bring:

We are looking for a student (f/m/d) with a background in biology, toxicology or a related field of study. You need to have scientific drive and willingness to achieve your scientific goals. Good English skills are mandatory, as we are an international working group and all meetings are held in English. Experience in cell culture and knowledge about common molecular and cellular analysis methods e.g. PCR, FACS, cell viability assays are a plus. A circumspect behavior inside and outside the lab and a good self-organization is needed to successfully work on this project.

What we offer:

We offer a scientifically inspiring working atmosphere with a broad variety of cell biological techniques to learn. We are a working group of 23 people that work in a team spirit. The topic you will work with is highly demanded in the field of alternative method research and up-to-date. We will help you to develop your skills in the laboratory work, data analyses and project presentation. The goal is a peer-reviewed publication of the data that you produce.


As early as possible.

Please submit your application (a short cover letter and your complete CV) by e-mail as one pdf-file to:

Prof. Dr. Ellen Fritsche
IUF – Leibniz-Institut für umweltmedizinische Forschung gGmbH
Auf’m Hennekamp 50
40225 Düsseldorf

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.