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If there is no suitable offer and you have a strong interest, you may send an application including cover letter, CV and certificates to: bewerbung@iuf-duesseldorf.de

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Master student (f/m/d)

The IUF-LIMES liaison group “innate immunity and extrinsic skin aging” offers a position for a Master student (f/m/d).

The position is suitable for a master student in the field of life sciences (biology, toxicology, molecular biomedicine, biochemistry, or similar) who aims to prepare a master’s thesis on immunology of the skin.

You will work on a DFG-funded project dealing with the impact of UV irradiation on the immune response in non-infectious inflammatory skin disorders. Specifically, we are interested in the functions of the transcription factor HIF-1a within the epidermis in a context of allergic skin disease.

Tasks include conventional PCR, primary cell isolation and culture, flow cytometry, histology, qPCR, Western blot, ELISA and related skills. Experience in any of these methods and their analysis will be a benefit. You are curious for doing basic research and are able to work as a responsible team member.

We offer a friendly and supportive working environment in close collaboration with other research groups within the interdisciplinary infrastructure of the IUF.

Please address your application (as one single pdf file) and any questions you may have, preferably via E-mail, to Sonja.Fassbender@IUF-Duesseldorf.de:

Dr. rer. nat. Sonja Faßbender
IUF – Leibniz-Institut für umweltmedizinische Forschung
Auf’m Hennekamp 50
40225 Düsseldorf

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.

Master Thesis position

The research group of Prof. Dr. Ellen Fritsche offers a Master Thesis position. Topic: 3D Bioprinting for Substance Development.

Toxicological screening is crucial for safety assessment of compounds, i.e. chemicals and pharmaceuticals. In line with the paradigm shift in toxicology, in vitro tests based on human cells are thought to be a predictive alternative to the apical animal testing that is currently still the gold standard for hazard assessment. To produce human cell-based neural in vitro systems for neurotoxicity testing is a challenge, especially due to the complexity of the human brain. One issue that needs tackling is the generation of neuronal networks for compound testing that can be produced stably and reproducibly in a relative short period of time in a multi-well format. The so far established networks using e.g. embryonic or induced pluripotent stem cells have a high variability and take a very long time to establish.

Therefore, in an interdisciplinary approach, the 3D bioprinting technology shall be used to fabricate hydrogel-based neuronal networks based on human induced pluripotent stem cell (iPSC)-derived neurons and glia cells for neurotoxicity in vitro testing. These organoid structures are thought to mimic human in vivo neuronal functions and are thus of interest for industrial medium-throughput applications.

For this challenging project, we seek for a highly motivated individual who has experience either with hydrogel preparation/characterization, stem cells, tissue engineering, 3D cell culture, or molecule crosslinking techniques. Ideally students of Biochemistry or Biomedical Engineering, or others with expertise in the mentioned research fields are welcome. Knowledge in Neurosciences, fluorescence imaging, IT affinity, and previous working experiences with cell cultures is a plus. We expect a team player with an outstanding commitment and fun at work. We offer an interdisciplinary and industrially funded project in Applied Science, an intensive on-the-job training, and a stimulating working atmosphere. Starting date is from December 2018.

Please send your application as one PDF file incl. cover/motivation letter and your CV to:

 

IUF – Leibniz-Institut für umweltmedizinische Forschung gGmbH

Dr. rer. nat. Ines Lauria

Auf’m Hennekamp 50

40225 Düsseldorf

Ines.Lauria@IUF-Duesseldorf.de