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If there is no suitable offer and you have a strong interest, you may send an application including cover letter, CV and certificates to: bewerbung@iuf-duesseldorf.de

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Post-Doc position (f/m/d)

The working group “Modern risk assessment and sphere biology” at the IUF - Leibniz Research Institute for Environmental Medicine in Düsseldorf is offering a Post-Doc position (f/m/d). The position is to be filled at IUF as of January 1st, 2019.

For screening of compounds for hazard assessment on the developing nervous system methods are desired that allow testing in a time- and cost-efficient manner in models with high physiological relevance. Therefore, the Fritsche lab has developed several 3D methods for developmental neurotoxicity (DNT) testing based on primary human and rodent neural progenitor cells (NPC), as well as human induced pluripotent stem cell (hiPSC)-derived NPC. These neurosphere-based systems mimic early neurodevelopmental processes like NPC proliferation, migration, differentiation into neurons and glial cells as well as apoptosis in vitro. To take our research to the next level we want to develop a new testing strategy for developmental neurotoxicity to meet the regulatory as well as scientific and societal needs of improved hazard and risk assessment of endocrine disrupting chemicals. Within an EU-funded project we want to establish links between neurodevelopmental endpoints and physiological endocrine pathways to develop a battery of assays for hazard identification, addressing endpoints relevant for human neurodevelopment linked to a clearly defined and empirically validated endocrine mode of action. The goal is to develop strategies to integrate these methods into European and international chemical regulatory frameworks and support the goals defined in the EU and World Health Organisation (WHO) environment and health process.

The successful applicant (f/m/d) holds a PhD degree in cell biology, molecular medicine or a closely related field and should have a strong interest in biomedical research in general, and (developmental)neurotoxicity and endocrine disruption in particular. You are a goal-oriented team player with excellent organizational and communication skills, including written and oral English. You have profound hands-on experience with primary cell culture and ideally with the development of novel screening methods for toxicity testing and development of SOPs. Knowledge in the fields of neurobiology/ neurotoxicology/endocrinology and first experiences in the culture of primary neuronal cells or hiPSC are advantageous but not mandatory.

We offer a very friendly and inspiring working atmosphere in an international team consisting of toxicologists, cell biologists, bioinformaticians and physicians. The successful candidate (f/m/d) will be invited to join the institute’s postdoc program, which, besides the scientific training, will impart multiple skills necessary for the development of an independent research career.

The position is limited until December 31, 2023. The weekly working time totals 39 hours and 50 minutes. Remuneration is given in accordance with the provisions of the collective agreement for the employees of the states (TV-L). Salary will be according to TV-L (E13).

Females are especially encouraged to apply, and in the case of equal qualification, handicapped persons will be given preference. The IUF is committed to family-friendly working conditions and equal gender policy.

Please submit your application by e-mail as one pdf-file combining relevant documents (letter of motivation, CV, university certificates, and contact of two referees) to: Bewerbung@IUF-Duesseldorf.de

Prof. Dr. Ellen Fritsche
IUF – Leibniz-Institut für umweltmedizinische Forschung gGmbH
Auf’m Hennekamp 50
40225 Düsseldorf

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.

Master Thesis position (f/m/d)

The working group “Modern risk assessment and sphere biology” at the IUF - Leibniz Research Institute for Environmental Medicine in Düsseldorf is offering a Master Thesis position (f/m/d).

Topic: Development of an autonomous, self-regulating in vitro cultivation platform

As part of a highly innovative, BMBF-funded, proof-of-concept study together with the Ruhr University Bochum, the Charité Berlin and the Max Delbrück Center for Molecular Medicine we want to establish an autonomous cultivation platform for complex in vitro models which will be used for studies on pathophysiological and toxicological endpoints as well as efficiency testing of substances. Therefore, as part of the master thesis, a bioreactor unit will be established in our lab and first proof of concept experiments will be performed using iPSC-derived 3D brain cell cultures in hydrogel. These brain spheres have to be cultured for 4 to 8 weeks in order to form neuronal networks. This process will be monitored either by analysis of different cell physiological parameters over time in the perfused bioreactor platform or analysis of neuronal activity and viability using 3D high content analysis (HCA) or light sheet fluorescent microscopy (LSFM).

We offer a very friendly and inspiring working atmosphere in an international team consisting of toxicologists, cell biologists, bioinformaticians and physicians. For this challenging project, we seek for a highly motivated master student (f/m/d) who has experience either with hydrogel preparation/characterization, stem cells, tissue engineering, or 3D cell culture. Ideally students of Biochemistry or Biomedical Engineering, or others with expertise in the mentioned research fields are welcome. Knowledge in Neurosciences, fluorescence imaging, IT affinity, and previous working experiences with cell cultures is a plus, excellent communication skills in German and English are mandatory. We expect a team player with an outstanding commitment and fun at work. Starting date is January 2019.

Please send your application as one PDF file incl. cover/motivation and your CV to Ellen.Fritsche@IUF-Duesseldorf.de

Prof. Dr. Ellen Fritsche
IUF – Leibniz-Institut für umweltmedizinische Forschung gGmbH
Auf’m Hennekamp 50
40225 Düsseldorf

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.                                                                                                          

Master Thesis position

The research group of Prof. Dr. Ellen Fritsche offers a Master Thesis position. Topic: 3D Bioprinting for Substance Development.

Toxicological screening is crucial for safety assessment of compounds, i.e. chemicals and pharmaceuticals. In line with the paradigm shift in toxicology, in vitro tests based on human cells are thought to be a predictive alternative to the apical animal testing that is currently still the gold standard for hazard assessment. To produce human cell-based neural in vitro systems for neurotoxicity testing is a challenge, especially due to the complexity of the human brain. One issue that needs tackling is the generation of neuronal networks for compound testing that can be produced stably and reproducibly in a relative short period of time in a multi-well format. The so far established networks using e.g. embryonic or induced pluripotent stem cells have a high variability and take a very long time to establish.

Therefore, in an interdisciplinary approach, the 3D bioprinting technology shall be used to fabricate hydrogel-based neuronal networks based on human induced pluripotent stem cell (iPSC)-derived neurons and glia cells for neurotoxicity in vitro testing. These organoid structures are thought to mimic human in vivo neuronal functions and are thus of interest for industrial medium-throughput applications.

For this challenging project, we seek for a highly motivated individual who has experience either with hydrogel preparation/characterization, stem cells, tissue engineering, 3D cell culture, or molecule crosslinking techniques. Ideally students of Biochemistry or Biomedical Engineering, or others with expertise in the mentioned research fields are welcome. Knowledge in Neurosciences, fluorescence imaging, IT affinity, and previous working experiences with cell cultures is a plus. We expect a team player with an outstanding commitment and fun at work. We offer an interdisciplinary and industrially funded project in Applied Science, an intensive on-the-job training, and a stimulating working atmosphere. Starting date is from December 2018.

Please send your application as one PDF file incl. cover/motivation letter and your CV to:

 

IUF – Leibniz-Institut für umweltmedizinische Forschung gGmbH

Dr. rer. nat. Ines Lauria

Auf’m Hennekamp 50

40225 Düsseldorf

Ines.Lauria@IUF-Duesseldorf.de

Student (f/m) for Master Thesis

The team of "UV-induced skin carcinogenesis and skin aging" lead by Prof. Petra Boukamp is looking for a student (f/m) for Master Thesis in the field of organotypic models and experimental sunlight.

Thesis topic:
Studies of single solar irradiation response in a human skin equivalent.

Our group is particularly interested in understanding the underlying biological mechanisms, which give rise to skin cancer. We use long-term skin equivalents (3D in-vitro models) that have been developed in our group to address questions related to the overall effects of sun exposure in models that represent not only normal adult skin, but also aged skin and different tumorigenic states.

Background to the topic:
Even though the influence of UV irradiation on our skin has been studied for many years, we still are lacking information regarding the biological effects of sun exposure as a whole. Until now most of research has been concentrating on the influence of UV. More recently we have also been able to add more knowledge by including infrared light and visual light (IRA, VIS). While this research was conducted either with single wavelength doses or sequential irradiation, sun doesn’t include a segmental or sequential form of irradiation, but a simultaneous exposure to UV, VIS and IRA. This is why our German consortia, KAUVIR (combination instead of addition: UV to IR radiation in skin cancer and skin aging), is studying the effects of sun exposure by using a state of the art lamp that allows simultaneous irradiations with spectra similar to the sun. These studies are essential in order to get a better understanding of the “damaging” effects of “sun light” and in consequence more relevant risk estimation and prevention.

The project:
In this master thesis you will be studying the immediate as well as the long-lasting effects of single UV and experimental sunlight exposure on a 3-D model of human skin. Endpoints that will be addressed are proliferation, differentiation and tissue damage.

Your background:
We are looking for a student (f/m) with a background in biology, toxicology or related field of study.

You will bring:
A practical Bachelor thesis. A great knowledge in English both spoken and written as you will be working in an international atmosphere. True interest in biological systems and bioengineering, which shows in the form of enthusiasm and high motivation. Furthermore our daily cell culture work and models require that you are meticulous in practical work and well organized both inside and outside the lab. It would be desirable if you have worked in a cell culture environment before.

What we can offer you:
We are a friendly and collaborative team that offers you the chance to develop your skills in the fields of skin biology, skin cancer and bioengineering.

Please address your application (a short cover letter and your CV), preferably electronically, to:
Prof. Petra Boukamp, p.boukamp@dkfz-heidelberg.de
and Dr. Elizabeth Pavez Loriè, elizabeth.pavezlorie@iuf-duesseldorf.de

IUF – Leibniz-Institut für umweltmedizinische Forschung
Auf’m Hennekamp 50
40225 Düsseldorf

We will contact you to arrange a meeting after the application deadline 3rd of September 2018.

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.